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CASE N°34 – Parotid gland, Warthin’s Tumor

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The Two Most Common Tumors of the Parotid Gland

Normal parotid gland

Low-magnification show admixture of acinar cells within lobules, small ducts & fibroadipose tissue.

Pleomorphic Adenoma

Pleomorphic adenoma is by far the most common salivary gland tumors comprising 50%-60% of all salivary gland neoplasm and approximately 60%-80% of parotid gland neoplasm


Combination of myoepithelial cells and mixoid matrix


Myoepithelial cells are embedded within a pale-staining fibrillary matrix


Cluster of myoepithelial cells and myxoid matrix



In May-Grunwald-Giemsa stain the matrix is magenta-purple

Warthin’s Tumor

Warthin’s tumor is usually cited as the second most common neoplasm and comprises 4%-14% of all salivary gland neoplasm


The characteristic findings are cohesive flat sheets of oncocytes and lymphocites



The oncocytes have abundant densely granular cytoplasm in a background of mixed population of lymphocytes


Note the absence of magenta-purple myxoid matrix

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