CASE N°14 – Cytology & Histology must go together
Mediastinal metastases from Renal
Cell Carcinoma (clear cell subtype)
Matiastinal lymphadenopathy PET+, in patient with no pulmonary nodules. Two years before diagnosis of Renal Cell Carcinoma (GradeII – clear cell subtype – see thumbnail).
Cytological material: Trans-Bronchial FNAC
Positive for malignancy.
Histological material: Trans-Bronchial FNAB
Clear Cell Renal Carcinoma metastases
In this case we have:
1) cytological speciemen in wich the morphology refer to the previous carcinoma. We cannot perform immunohistochemistry on cytological speciemen due to scant cellularity.
2) histological speciemen with few cells so it is hard to say “ok, metastases”. Fortunately here we can perform immunohistochemistry tha is coherent with the previously diagnosed carcinoma.
Finally 1+2 = correct diagnosis