CASE N°08 – Thyroid carcinoma mimicking adenoid cystic carcinoma
multinodular thyroid gland. In the past she underwent therapy with 131-I for hyperthyroidism. Conclusions: multinodular goiter
Cytological material: Thyroid FNA
Positive for malignant cells.
After cytological diagnosis she underwent CAT (computerized axial tomography):
Both lungs with many and diffuse nodular lesions of pathological meaning. Numerous adenopathy at the level of the main mediastinal stations. Hepatic parenchyma with focal lesion, 1 cm in diameter, of pathological meaning.
Hystological material: Thyroidectomy
Poorly differentiated thyroid carcinoma.
Spherical hyaline globules are characteristic finding in Salivary Gland Tumors but are rare in thyroid tumors: few cases are reported in literature with this pattern in thyroid pathology.
Poorly differentiated thyroid carcinoma may present with multiple cytological picture (hyaline globules included); we must keep in mind this aspect, with the scope not to commit erroneous diagnoses. Immunohistochemically the tumor cell were positive for Thyroglobulin. Also take a look to the Alcian-PAS stain.