CASE N°06 – Hyalinizing trabecular adenoma of the thyroid gland

CASE N°06 – Hyalinizing trabecular adenoma of the thyroid gland

Clinical History:

Age: 70

Sex:  Female

hypothyroidism due to autoimmune thyroiditis

Ecography: multiples thyroid nodules

Scintigraphy: negative. Thyroid goiter

Cytological Images:

Cytological speciemen:  isthmic nodule, FNAC

PAP 20X

PAP 40X

H/E 20X

Cytological Report:

Scant cellularity. Tireocytes with mild anisocaryosis, sometimes with intra-nuclear cytoplasmic inclusions. Scant colloid. Suspicious but non conclusive for Papillary Thyroid Carcinoma. Histology confirmation needed.

Histological Images:

Histological material:  Thyroidectomy

 

Histological Report:

Hyalinizing trabecular adenoma of the thyroid gland. Immunohistochemistry: MIB1-ki 67(+ membrane) , CK19(+), Galectin3(-).

Discussion:

Hyalinizing trabecular adenoma is an uncommon benign thyroid tumor that can present as a solitary thyroid nodule, a prominent nodule in a multinodular goiter The clinical significance of the lesion is that it is frequently misdiagnosed as papillary carcinoma on fine-needle aspiration cytology.

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