CASE N°06 – Hyalinizing trabecular adenoma of the thyroid gland
hypothyroidism due to autoimmune thyroiditis
Ecography: multiples thyroid nodules
Scintigraphy: negative. Thyroid goiter
Cytological speciemen: isthmic nodule, FNAC
Scant cellularity. Tireocytes with mild anisocaryosis, sometimes with intra-nuclear cytoplasmic inclusions. Scant colloid. Suspicious but non conclusive for Papillary Thyroid Carcinoma. Histology confirmation needed.
Histological material: Thyroidectomy
Hyalinizing trabecular adenoma of the thyroid gland. Immunohistochemistry: MIB1-ki 67(+ membrane) , CK19(+), Galectin3(-).
Hyalinizing trabecular adenoma is an uncommon benign thyroid tumor that can present as a solitary thyroid nodule, a prominent nodule in a multinodular goiter The clinical significance of the lesion is that it is frequently misdiagnosed as papillary carcinoma on fine-needle aspiration cytology.