CASE N°16 – Pancreas: Neuroendocrine Neoplasm

Clinical History:

Age: 60

Sex: Male

Episode of acute pancreatitis 3 months ago. At the last review of magnetic resonance imaging detection of  lesion (about 19 mm in diameter) located in the body.

Cytological Images:

Cytological material: Pancreatic EUS-FNA

  Pap 40x

 Pap 100x

 Pap 200x

 Pap 400x

 Pap 400x

 Cytoblock

 Chromogranin

 Synaptofisin

Cytological Report:

Cellular aspirates, loosely cohesive cell groups, rosette or pseudorosette formation, relatively uniform, round-to-polygonal tumor cells, salt & pepper chromatin pattern. Immunohistochemistry (cytoblock) shows rectivity for Cromogranin  & Synaptofisin. Neuroendocrine neoplasm.

Discussion:

Pancreatic endocrine tumors are uncommon, often are asymptomatic or present with nonspecific symptoms. There is no sex predilection. Tumors can devolop anywere within the pancreas but are more common in the pancreatic tail.

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