CASE N°13 – Small Cell Lung Carcinoma
Chest pain & assiociated weight loss, smoker (20 cigarettes/die). Chest radiography & computed tomography revealed cemtrally located lung mass about 3 cm in diameter with extensive necrosis. No other pathological findings. Bronchoscopy+biopsy was performed.
Cytological material: Trans-Bronchial FNAC
Positive for malignancy. Neoplastic cells with increased N/C ratio, scant cytoplasm, finely granular chromatin pattern, nuclear molding, crush artifact & necrosis are consistent with small cell lung carcinoma.
Histological material: Trans-Bronchial FNAB
Neuroendocrine small cell lung carcinoma
Small cell lung carcinoma (SCLC) is the most aggressive form of lung cancer. It usually starts in the bronchi and grow very quickly creating large tumors. Often spread rapidly (metastasize) to other parts of the body, including the brain, liver, and bone.
SCLC is highly sensitive to chemotherapy. Response rates vary between 50-90% depending on the stage of disease and the patient’s tolerance of the chemotherapy.