CASE N°09 – Medullary Thyroid carcinoma
Check up: occasional reply of multinodular goiter. Right lobe: calcify nodule about 2 cm. in diameter, cytology examination was suggested.
Cytological material: Thyroid FNA
Positive for malignant cells. Possible medullary thyroid carcinoma.
Hystological material: Thyroidectomy
Medullary thyroid carcinoma.
Cytology pictures: neoplastic cells are organized in aggregates and isolated, sometimes with elongated nuclei and “salt & pepper” chromatin pattern. Isolated cells presents with eccentric nuclei and with Giemsa stain they have metachromatic cytoplasm.
Medullary carcinoma is the third most common of all thyroid cancers (5 to 8 %). This type of Tumors arise from the parafollicular cells (also called C cells) of the thyroid, placed to the calcitonina production (thus their name). Medullary carcinoma has a much lower cure rate than papillary and follicular carcinomas, but higher than anaplastic thyroid cancer.