CASE N°19 – Bone Plasmacytoma

Clinical History:

Age: 33

Sex: male

Physical examination: about a year sickness, pain in the neck, dizziness

CT-SCAN: lytic lesion about 2 cm, localized in the soft tissue around the cervical vertebra n°6

Cytological Images:

Cytological material: trans-cutaneous FNAC

Cytological Report:

Isolated cell pattern, eccentric nuclei. Suspected lymphoproliferative disease. Histological verification is raccomended to estabilish the final diagnosis.

Histological Images:

Histological material: spinal tumor, excision

   kappa light chains+

   lambda light chain-



Histological Report:

Localization of bone plasmacytoma kappa monoclonal antibody.

Immunophenotype: CD138+,  kappa light chains+, lambda light chain-, CD1a-


Plasmacytoma refers to a malignant plasma cell tumor growing within soft tissue or within the skeleton. The skeletal forms usually have other occult tumors and frequently disseminate to multiple myeloma over the course of 5–10 years. The soft tissue forms most often occur in the upper respiratory tract, rarely disseminate, and are cured by resection. Most but not all cases produce paraproteinemia. Solitary tumors in bone can be treated by radiotherapy


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