CASE N°10 – Submandibular Lymph node

Clinical History:

Age: 55

Sex:  Male

During follow-up in autoimmune thyroiditis the echography showed Lymph node enlargement below angle of jaw, 16 mm in diameter

Cytological Images:

Cytological material: Lymph node F.N.A.

fig.1 PAP 100x

fig.2  PAP 400x

fig.3  PAP 400x

fig.4  PAP 40x

Cytological Report:

Positive for malignancy: keratinizing squamous cell carcinoma

Histological Images:

Histological material: Lymph node excision

 HE 40x

HE 100x

Histological Report:

Keratinizing squamous cell carcinoma.


Squamous cell carcinoma is a common primary head and & neck malignant neoplasm. The risk factors (sun exposure, tobacco & alcohol) are well recognized. It is usually restricted to the mucosal surfaces of the upper aerodigestive tract and skin; in fact after our diagnosis the clinician discovered the primary site of the neoplasm that was located under the tongue.

Cytology show corneous pearls formation (fig 4) besides malignant squamous cells, sometimes with keratinazed cytoplasm (fig 1-3). Histology showed the same cell pattern.

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