CASE N°05 – Papillary Adenocarcinoma of Lung

Clinical History:

Age: 61

Sex:  Female

Productive cough, shortness of breath and weight loss

Thorax CT: single pulmonary nodule in the lower lobe of the right lung, 2 cm in diameter

Abdominal CT: negative.The patient underwent thoracotomy for nodule excision

Cytological Images:

Cytological speciemen:  Trans-Thoracic FNA

PAP 100X

PAP 400X

H/E 100X

H/E 400X

Cytological Report:

Papillary aggregates containing fibrovascular cores, lined by  atypical cells with enlarged, hyperchromatic nuclei, prominent nucleoli  and few intranuclear vacuoles.

Pulmonary adenocarcinoma with papillary growth pattern.

Histological Images:

Histological material: Lung Nodule Excision

H/E 100X

H/E 200X

Histological Report:

Papillary adenocarcinoma of Lung

Discussion:

Papillary carcinoma of the lung is a distinct clinicopathologic entity with considerably worse morbidity and mortality than bronchioloalveolar carcinoma. This unusual histopathological growth pattern is characterized by complex papillary infoldings

In most cases, areas of adenocarcinoma or bronchioloalveolar carcinoma can be identified. Pure form need to be distinguished from other types of tumours (Eg: thyroid gland or ovary).

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