CASE N°02 – Solid pseudopapillary neoplasm of pancreas

Clinical History:

Age: 31

Sex:  Female

Painless abdominal mass in the epigastric region.

CT-Scan: The tumour was located in the pancreatic tail, size was about 10cm.

Cytological Images:

Cytological specimen: EUS-guided FNAC of pancreas


PAP 100X


Cytological Report:

Highly cellular specimen characterized by the presence of epithelial cells that present in pseudopapillary aggregates containing fibrovascular cores, with bland appearing tumour cells. No evidence of pleomorphism or mitotic activity is seen in the cells.

Cytological report consistent with solid pseudopapillary neoplasm.

Histological Images:

Hystological material: Core Biopsy of Pancreas


vimentin +

Beta-catenin +

Histological Report:

Solid pseudopapillary neoplasm.

Immunohistochemistry: Vimentin+, Beta catenin+.


Solid pseudopapillary neoplasm (SPN) of pancreas is a rare entity; therefore proper diagnosis, evaluation and formulation of treatment protocols is difficult; females in the second/third decade are most frequently affected.

The histogenesis of these tumours is unknown but they possibly originate from the primordial cells and lack definite endocrine and exocrine differentiation.

Patients with SPN have an excellent prognosis after surgical excision.

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